Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study.

@article{Mira1999AssociationOT,
  title={Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study.},
  author={J P Mira and Alain Cariou and Franck Grall and Christophe Delclaux and Marie Reine Losser and Farhad Heshmati and Christine Cheval and Mehran Monchi and Jean Louis Teboul and Florence Rich{\'e} and Ghislaine Leleu and Laurence Arbibe and Alexandre Mignon and Marcelo Delpech and Jean Francois Dhainaut},
  journal={JAMA},
  year={1999},
  volume={282 6},
  pages={
          561-8
        }
}
CONTEXT Tumor necrosis factor alpha (TNF-alpha) is believed to be a cytokine central to pathogenesis of septic shock. TNF2, a polymorphism within the TNF-alpha gene promoter, has been associated with enhanced TNF-alpha production and negative outcome in some severe infections. OBJECTIVES To investigate the frequency of the TNF2 allele in patients with septic shock and to determine whether the allele is associated with the occurrence and outcome of septic shock. DESIGN Multicenter case… CONTINUE READING
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