Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population.

@article{Boraska2008AssociationOT,
  title={Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population.},
  author={Vesna Boraska and Veselin {\vS}krabi{\'c} and Vedrana Cikes Culi{\'c} and Kristijan Be{\vc}i{\'c} and Sanja Kapitanovic and Tatijana Zemunik},
  journal={Biological research},
  year={2008},
  volume={41 2},
  pages={
          157-63
        }
}
Type 1 diabetes mellitus (TIDM) is an autoimmune disease characterized by the destruction of pancreatic p cells. Tumor necrosis factor (TNF) is a pleotropic cytokine with potent immunomodulatory and inflammatory activity. Association studies of TNF polymorphisms and type 1 diabetes (TIDM) frequently demonstrated TNF involvement with TIDM. Although TNF may play an important role in the pathogenesis of TIDM, the genetic association of TNF región with the disease has not been conclusive because of… CONTINUE READING

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