Association of TNFα, TNFR1, and TNFR2 polymorphisms with sperm concentration and motility.

@article{Lazaros2012AssociationOT,
  title={Association of TNFα, TNFR1, and TNFR2 polymorphisms with sperm concentration and motility.},
  author={Leandros A. Lazaros and Nectaria V. Xita and Anthoula L Chatzikyriakidou and Apostolos I. Kaponis and Nicolaos G Grigoriadis and Elissavet G. Hatzi and Ioannis G Grigoriadis and Nikolaos Sofikitis and Konstantinos A. Zikopoulos and Ioannis A. Georgiou},
  journal={Journal of andrology},
  year={2012},
  volume={33 1},
  pages={74-80}
}
Tumor necrosis factor α (TNFα) is a multifunctional cytokine that regulates various cellular processes related to spermatogenesis. Two types of cell receptors, TNFR1 and TNFR2, mediate TNFα activity. In the present study, we sought to explore the association of TNFα -857C→T, TNFR1 36A→G, and TNFR2 676T→G polymorphisms with sperm concentration and motility. Two hundred ninety men were examined during infertility investigation; of those, 170 men were normozoospermic and 120 were oligospermic… CONTINUE READING
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