Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer risk and survival.

@article{Zeljic2014AssociationOT,
  title={Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer risk and survival.},
  author={Katarina Zeljic and Gordana Supi{\'c} and Neboj{\vs}a Jovi{\'c} and Ru{\vz}ica Kozomara and Mirjana V. Brankovic-Magic and Milan R Obrenovi{\'c} and Zvonko Magi{\'c}},
  journal={Oral diseases},
  year={2014},
  volume={20 4},
  pages={416-24}
}
OBJECTIVES The aim of this study is to investigate association between polymorphisms in TLR2, TLR3, TLR4 and CD14 genes or their haplotypes with oral squamous cell carcinomas (OSCC) risk and survival. METHODS The study was conducted on 93 OSCC patients and 104 cancer-free controls. Polymorphisms were genotyped by real-time PCR or PCR-RFLP method. RESULTS Significant increase in oral cancer risk was observed in individuals with mutated genotype of TLR3 rs3775291 polymorphism (OR = 1.096, P… CONTINUE READING
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