Association of TIM4 promoter polymorphism -1419G>A with childhood asthma in a Chinese Han population.

@article{Cai2009AssociationOT,
  title={Association of TIM4 promoter polymorphism -1419G>A with childhood asthma in a Chinese Han population.},
  author={P C Cai and Li Hua Hu and Tian-pen Cui and Yun Rose Li and Fen Hua Chen and Qiao Wu},
  journal={Tissue antigens},
  year={2009},
  volume={74 1},
  pages={11-6}
}
TIM4, which is expressed on dendritic cells and macrophages, plays an important role in the proliferation of T helper type 2 (Th2) cells. Asthma, as a complex genetic disease, is thought to arise from the development of a Th2-lymphocyte-predominant immune response. To evaluate the effects of the promoter polymorphisms (-1419G>A and -1609G>A) in TIM4 on asthma susceptibility, case-control and family-based association studies were conducted by polymerase chain reaction and restriction fragment… CONTINUE READING