Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5).

@article{Zampetti2010AssociationOT,
  title={Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5).},
  author={Simona Zampetti and Marialuisa Spoletini and Antonio Petrone and Marco Capizzi and Maria Luisa Arpi and Claudio Tiberti and Sergio di Pietro and Emanuele Bosi and Paolo Pozzilli and Francesco Giorgino and Raffaella Buzzetti},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2010},
  volume={27 6},
  pages={701-4}
}
AIMS We previously demonstrated the presence of two different populations among adult-onset autoimmune diabetes (latent autoimmume diabetes of adults; LADA) having high or low titre of antibodies to glutamic acid decarboxylase (GADA). The transcription factor 7-like 2 (TCF7L2) gene has been recognized as the major gene associated with Type 2 diabetes. The aim of the present study was to evaluate whether the phenotypic heterogeneity of LADA based on GADA titre is associated with TCF7L2… CONTINUE READING

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