Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.

@article{Palmer2008AssociationOT,
  title={Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.},
  author={Nicholette D. Palmer and Allison B. Lehtinen and Carl D. Langefeld and Joel K. Campbell and Steven M. Haffner and Jill M Norris and Richard N Bergman and Mark O Goodarzi and Jerome I. Rotter and Donald W. Bowden},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2008},
  volume={93 1},
  pages={304-9}
}
CONTEXT Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined. OBJECTIVE The objective of this study was to evaluate previously associated variants for association with measures of glucose homeostasis in Hispanic-Americans and African-Americans and determine the biological mechanism(s) through which these variants exert their effect… CONTINUE READING