Association of T916C (Y257H) mutation in Candida albicans ERG11 with fluconazole resistance.

@article{Zhao2013AssociationOT,
  title={Association of T916C (Y257H) mutation in Candida albicans ERG11 with fluconazole resistance.},
  author={J. R. Zhao and Yonghao Xu and Chunyang Li},
  journal={Mycoses},
  year={2013},
  volume={56 3},
  pages={315-20}
}
Repeated and prolonged use of fluconazole in treating candidosis leads to drug resistance. The aim of this study was to confirm the relationship between T916C (Y257H) mutation in Candida albicans ERG11 and fluconazole resistance. We replaced one copy of ERG11 with ERG11 containing the T916C mutation in C. albicans CAI4 and expressed ERG11 with the T916C mutation in Saccharomyces cerevisiae INVSc1. The MIC values were two- to four-fold greater in CAI4 transformants with than without the T916C… CONTINUE READING