Association of Sphingosine‐1‐phosphate (S1P)/S1P Receptor‐1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma

@inproceedings{Rodriguez2015AssociationOS,
  title={Association of Sphingosine‐1‐phosphate (S1P)/S1P Receptor‐1 Pathway with Cell Proliferation and Survival in Canine Hemangiosarcoma},
  author={A. M. Rodriguez and A. J. Graef and D. N. LeVine and I. R. Cohen and J Modiano and J.‐H. Kim},
  booktitle={Journal of veterinary internal medicine},
  year={2015}
}
BACKGROUND Sphingosine-1-phosphate (S1P) is a key biolipid signaling molecule that regulates cell growth and survival, but it has not been studied in tumors from dogs. HYPOTHESIS/OBJECTIVES S1P/S1P1 signaling will contribute to the progression of hemangiosarcoma (HSA). ANIMALS Thirteen spontaneous HSA tissues, 9 HSA cell lines, 8 nonmalignant tissues, including 6 splenic hematomas and 2 livers with vacuolar degeneration, and 1 endothelial cell line derived from a dog with splenic hematoma… CONTINUE READING
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