Association of Single Nucleotide Polymorphisms of the MDM4 Gene With the Susceptibility to Breast Cancer in a Southeast Iranian Population Sample

@article{Hashemi2018AssociationOS,
  title={Association of Single Nucleotide Polymorphisms of the MDM4 Gene With the Susceptibility to Breast Cancer in a Southeast Iranian Population Sample},
  author={Mohammad Hashemi and Sara Sanaei and Seyeh Mehdi Hashemi and E Eskandari and Gholamreza Bahari},
  journal={Clinical Breast Cancer},
  year={2018},
  volume={18},
  pages={e883–e891}
}

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Considering the lack of association between MDM4 rs4245739 polymorphism and breast cancer, polymorphism of this gene seems to have no significant role in the pathophysiology of the disease.
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Considering the lack of any observed association between the MDM4 rs4245739 polymorphism and TC, it is concluded no significant role in the pathophysiology of the disease is concluded.
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The findings showed that rs1406 C/A polymorphism increased the risk of BC in codominant (OR 1.60, 95 % CI 1.22–2.56, p = 0.012 CA + AA vs CC) inheritance models, indicating that CCNE1 rs 1406 polymorphism may contribute to BC risk.
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The pooled results revealed that the MDM4 rs4245739C allele is associated with a decreased cancer risk in the heterozygous (AC vs. AA): ORs and 95% confidence intervals were used and the association was more prominent in Asians and population-based studies.
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A combinational effect between MDM4 rs4245739 and P53 Arg72Pro variants in attenuating breast cancer risk is observed, highlighting the importance of the P53 tumor suppressor pathway genes during malignant transformation and supporting the hypothesis that genetic variants interrupting miRNA-mediated gene regulation might be important genetic modifiers of breast cancerrisk.
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The results elucidate that the MDM4 rs4245739 polymorphism contributes to susceptibility of ESCC and support the hypothesis that genetic variants, interrupting miRNA-mediated gene regulation, may modify cancer risk.
A Regulatory MDM4 Genetic Variant Locating in the Binding Sequence of Multiple MicroRNAs Contributes to Susceptibility of Small Cell Lung Cancer
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The data illuminate that the MDM4rs4245739SNP contributes to SCLC risk and support the notion that gene 3’-UTR genetic variants, impacting miRNA-binding, might modify SclC susceptibility.
Association Between Vascular Endothelial Growth Factor Gene Polymorphisms with Breast Cancer Risk in an Iranian Population
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