Association of Single Nucleotide Polymorphisms in CYP1B1 and COMT Genes with Breast Cancer Susceptibility in Indian Women

@inproceedings{Yadav2009AssociationOS,
  title={Association of Single Nucleotide Polymorphisms in CYP1B1 and COMT Genes with Breast Cancer Susceptibility in Indian Women},
  author={Sharawan Yadav and Naveen Kumar Singhal and Virendra Singh and Neeraj Rastogi and Pramod K. Srivastava and Mahendra Pratap Singh},
  booktitle={Disease markers},
  year={2009}
}
Cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) enzymes play critical roles in estrogen metabolism. Alterations in the catalytic activity of CYP1B1 and COMT enzymes have been found associated with altered breast cancer risk in postmenopausal women in many populations. The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT… CONTINUE READING

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