Association of SRD 5 A 2 Genotype and Pathological Characteristics of Prostate Tumors 1

  title={Association of SRD 5 A 2 Genotype and Pathological Characteristics of Prostate Tumors 1},
  author={J. Michael Jaffe and Stanley Bruce Malkowicz and Amy H. Walker and S J Macbride and Richard E Peschel and John P. Tomaszewski and Keith N. Van Arsdalen and Alan J. Wein and Timothy R. Rebbeck},
The enzyme product ofSRD5A2, 5a-reductase type II, is responsible for converting testosterone to the more metabolically active dihydrotestosterone. Therefore,SRD5A2 may be involved in the development or growth of prostate tumors. To examine the effects of allelic variants in the geneSRD5A2on the presentation of prostate tumors, we studied a sample, primarily Caucasian, of 265 men with incident prostate cancer who were treated by radical prostatectomy. We assessed the relationship of the A49T… CONTINUE READING
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