Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population.

@article{Kato2003AssociationOS,
  title={Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese population.},
  author={Atsushi Kato and Kazuyoshi Fukai and Naoki Oiso and Naoko Hosomi and Takashi Murakami and Masamitsu Ishii},
  journal={The British journal of dermatology},
  year={2003},
  volume={148 4},
  pages={665-9}
}
BACKGROUND Netherton's syndrome (NS) is an autosomal recessive disorder characterized by trichorrhexis invaginata ('bamboo hair'), congenital ichthyosiform erythroderma and an atopic diathesis. NS has recently been shown to be due to a defect in the SPINK5 gene, encoding LEKTI, a 15-domain serine protease inhibitor. SPINK5 maps to chromosome 5q31-q32, and has been suggested to be a locus predisposing to atopy in general. Recently, coding polymorphisms in SPINK5 exons 13 and 14 have been… CONTINUE READING