Association of SNPs and haplotypes in GABAA receptor β2 gene with schizophrenia

@article{Lo2004AssociationOS,
  title={Association of SNPs and haplotypes in GABAA receptor $\beta$2 gene with schizophrenia},
  author={W. Lo and C. Lau and Z. Xuan and C-F Chan and G. Feng and L. He and Zhirui Cao and H. Liu and Qin Luan and H. Xue},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={603-608}
}
Disturbances in GABAergic system have been observed in schizophrenics.1,2,3 In the present study, population association analysis was performed on 19 SNPs in the α1, β2, γ2, ɛ and π subunit genes of GABAA receptor. Five SNPs in GABRB2, namely B2I7G1584T, rs1816071, rs194072, rs252944 and rs187269, were found to be significantly associated, and their haplotypes in linkage disequilibrium, with schizophrenia. This represents the first report on any disease association of SNPs in the human GABAA… Expand
Association Analysis of Chromosome 5 GABAA Receptor Cluster in Japanese Schizophrenia Patients
TLDR
The results indicate that this GABA(A) receptor gene cluster may not play a major role in Japanese schizophrenia and raised an alert with regard to preliminary genetic association analysis using a small sample size. Expand
Positive Selection within the Schizophrenia-Associated GABAA Receptor β2 Gene
TLDR
Electrophysiological analysis showed that this long β2 isoform favored by the positive selections is more sensitive than the short isoform to the inhibition of GABAA receptor function by energy depletion, the first demonstration of positive selection in a schizophrenia-associated gene. Expand
Association study of the gamma-aminobutyric acid type a receptor γ2 subunit gene with schizophrenia
TLDR
The results of the present study suggest that GABRG2 may be involved in SCZ susceptibility, but further studies are required. Expand
GABRB 2 in schizophrenia and bipolar disorder : disease association , gene expression and clinical correlations
The SCZ (schizophrenia)-associated GABAA receptor (γ -aminobutyric acid type A receptor) β2 subunit gene GABRB2 was recently associated with BPD (bipolar disorder). Although weaker than itsExpand
The association of GABRB2 SNPs with cognitive function in schizophrenia
TLDR
It was found that the allele G of rs187269 in the GABRB2 gene was significantly associated with better cognitive flexibility, a major aspect of executive function, in patients with first episode schizophrenia, suggesting that modulating GAB RB2 may have therapeutic potential to improve cognitive function of patients with schizophrenia. Expand
Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population.
TLDR
Two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia by genotyping five SNPs and additional rs1816072 in 352 Chinese Han family trios. Expand
Comprehensive association analysis of 27 genes from the GABAergic system in Japanese individuals affected with schizophrenia
TLDR
Substantiating genetic evidence is provided for the involvement of the GABAergic system in schizophrenia susceptibility and Haplotypes containing associated variants in GABRA1 but not GPHN were significantly associated with schizophrenia. Expand
Gene Association Studies of Schizophrenia and Tardive Dyskinesia
TLDR
This analysis investigated the GABAA receptor γ2 subunit gene GABRG2, the dopamine receptor gene DRD3, and the Brain-derived neurotrophic factor gene BDNF that is required for D3 expression by genotyping polymorphisms spanning and surrounding these genes for association with SCZ, as well as suicidal behaviour. Expand
GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations.
TLDR
The findings highlight the importance of GABRB2 in neuropsychiatric disease aetiology, with respect to haplotype association, as well as reduction of and temporal effects on gene expression in both SCZ and BPD, but to a lesser extent in the latter, supporting the suggestion that functional psychosis can be conceptualized as a continuous spectrum of clinical phenotypes rather than as distinct categories. Expand
Two isoforms of GABAA receptor β2 subunit with different electrophysiological properties: differential expression and genotypical correlations in schizophrenia
TLDR
Genotype-dependent expression of the alternatively spliced isoforms of GABAA receptor β2 subunit gives rise to electrophysiological consequences that could play an important role in the pathogenesis mechanism of schizophrenia. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 33 REFERENCES
Positive association of the AMPA receptor subunit GluR4 gene (GRIA4) haplotype with schizophrenia: Linkage disequilibrium mapping using SNPs evenly distributed across the gene region
  • C. Makino, Y. Fujii, +7 authors Y. Fukumaki
  • Biology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2003
TLDR
The results suggest that at least one susceptibility locus for schizophrenia is located within or very close to the GRIA4 region in Japanese. Expand
Neuregulin 1 and susceptibility to schizophrenia.
TLDR
The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia. Expand
A highly significant association between a COMT haplotype and schizophrenia.
TLDR
An efficient approach to gene discovery is reported that found a highly significant association between schizophrenia and a COMT haplotype and can be widely implemented for the genetic dissection of other common diseases. Expand
Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia
TLDR
A map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from chromosome 13q34 that has been genetically linked to schizophrenia, pointing to the involvement of this N-methyl-d-aspartate receptor regulation pathway in schizophrenia. Expand
Differential expression of GABAA receptor subunit mRNAs and ligand binding sites in rat brain following phencyclidine administration
TLDR
The results indicate that single and repeated administrations of PCP independently regulate the expression of GABAA/benzodiazepine (BZD) receptor subunits mRNA and its receptor binding in the brain. Expand
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study.
TLDR
The selective down-regulation of RELN and GAD(67) in prefrontal cortex of patients with schizophrenia and bipolar disorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis; this plus the loss of the correlation between these 2 parameters that exists in nonpsychotic subjects support the hypotheses that these changes may be liability factors underlying psychosis. Expand
Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex.
TLDR
The selective nature of the changes in serotonin2A and GABA(A) receptors in DLPFC could indicate that these changes are involved in the pathology of schizophrenia. Expand
Genes, environment and schizophrenia.
TLDR
Schizotaxia provides a useful way to conceptualise both the liability for schizophrenia, and also the development of treatment strategies aimed at the eventual prevention of the illness. Expand
An update on GABAA receptors
TLDR
The subunit requirement of various drugs such as anxiolytics, anticonvulsants, general anesthetics, barbiturates, ethanol and neurosteroids, which are known to elicit at least some of their pharmacological effects via the GABAA receptors, have been investigated during the last few years so as to understand their exact mechanism of action. Expand
Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia.
TLDR
The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations. Expand
...
1
2
3
4
...