Association of SNPs and haplotypes in GABAA receptor β2 gene with schizophrenia

@article{Lo2004AssociationOS,
  title={Association of SNPs and haplotypes in GABAA receptor $\beta$2 gene with schizophrenia},
  author={Wing Sze Lo and Ching-Fun Lau and Zhen Yu Xuan and C-F Chan and Guo-yin Feng and L. He and Zhirui Cao and H. Y. Liu and Qin Luan and Hong Xue},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={603-608}
}
  • W. LoC. Lau H. Xue
  • Published 1 June 2004
  • Medicine, Psychology
  • Molecular Psychiatry
Disturbances in GABAergic system have been observed in schizophrenics.1,2,3 In the present study, population association analysis was performed on 19 SNPs in the α1, β2, γ2, ɛ and π subunit genes of GABAA receptor. Five SNPs in GABRB2, namely B2I7G1584T, rs1816071, rs194072, rs252944 and rs187269, were found to be significantly associated, and their haplotypes in linkage disequilibrium, with schizophrenia. This represents the first report on any disease association of SNPs in the human GABAA… 

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