Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin

@inproceedings{Smith2012AssociationOR,
  title={Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin},
  author={Andrew Lee Smith and Michael Robert Dohn and Meredith V. Brown and Albert B. Reynolds},
  booktitle={Molecular biology of the cell},
  year={2012}
}
The dynamic functional linkage of cadherins with the underlying actin cytoskeleton is tightly regulated to achieve proper cell-cell adhesion. p120-catenin (p120) regulates both cadherin stability and actin dynamics, but the relationship between these two functions remains unclear. Using a novel proteomic approach called reversible cross-link immunoprecipitation, or ReCLIP, we previously identified a physical interaction between p120 and Rho-associated protein kinase 1 (ROCK1), a major effector… CONTINUE READING

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