Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons.

@article{FajardoSerrano2013AssociationOR,
  title={Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons.},
  author={Ana Fajardo-Serrano and Nicole Wydeven and Daniele Young and Masahiko Watanabe and Ryuichi Shigemoto and Kirill A Martemyanov and Kevin Wickman and Rafael Luj{\'a}n},
  journal={Hippocampus},
  year={2013},
  volume={23 12},
  pages={1231-45}
}
In the hippocampus, signaling through G protein-coupled receptors is modulated by Regulators of G protein signaling (Rgs) proteins, which act to stimulate the rate of GTP hydrolysis, and consequently, G protein inactivation. The R7-Rgs subfamily selectively deactivates the G(i/o)-class of Gα subunits that mediate the action of several GPCRs. Here, we used co-immunoprecipitation, electrophysiology and immunoelectron microscopy techniques to investigate the formation of macromolecular complexes… CONTINUE READING

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