Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model.

@article{Sheean2018AssociationOR,
  title={Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis: A Study of Humans and a Transgenic Mouse Model.},
  author={Rebecca K. Sheean and Fiona C. McKay and Erika Cretney and Christopher R. Bye and Nirma D. Perera and Doris Tomas and Richard A Weston and Karlene J. Scheller and Elvan Djouma and Parvathi Menon and Stephen Donald Schibeci and Najwa Marmash and Justin J Yerbury and Stephen L Nutt and David M. Booth and Graeme John Stewart and Mathew C. Kiernan and Steve Vucic and Bradley J. Turner},
  journal={JAMA neurology},
  year={2018},
  volume={75 6},
  pages={
          681-689
        }
}
Importance Neuroinflammation appears to be a key modulator of disease progression in amyotrophic lateral sclerosis (ALS) and thereby a promising therapeutic target. The CD4+Foxp3+ regulatory T-cells (Tregs) infiltrating into the central nervous system suppress neuroinflammation and promote the activation of neuroprotective microglia in mouse models of ALS. To our knowledge, the therapeutic association of host Treg expansion with ALS progression has not been studied in vivo. Objective To… CONTINUE READING
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