Association of Reduced Type IX Collagen Gene Expression in Human Osteoarthritic Chondrocytes With Epigenetic Silencing by DNA Hypermethylation

Abstract

OBJECTIVE To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. METHODS Expression levels were determined using quantitative reverse transcription-polymerase chain reaction, and the percentage of DNA… (More)
DOI: 10.1002/art.38774

Topics

6 Figures and Tables