Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians.

@article{Korolija2009AssociationOP,
  title={Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with Type 1 Diabetes in Croatians.},
  author={Marina Korolija and Ivana Pavli{\'c} Renar and Mirko Hadzija and Edita Pape Medvidovi{\'c} and Pajica Pavkovi{\'c} and Mladen Joki{\'c} and Marijana Popovic Hadzija},
  journal={Diabetes research and clinical practice},
  year={2009},
  volume={86 3},
  pages={e54-7}
}
In this case-control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n=102) and control (n=193) groups differ significantly (p<0.0001 and p=0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele (p<0.0001… CONTINUE READING

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