Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort

@article{Thorburn2007AssociationOP,
  title={Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort},
  author={Christine M Thorburn and Ludmila Prokunina-Olsson and Kirsten Sterba and Raymond Lum and Michael F. Seldin and Marta E. Alarc{\'o}n-Riquelme and Lindsey A. Criswell},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={279-287}
}
We evaluated the roles of five single-nucleotide polymorphisms (SNPs) within PDCD1, and haplotypes defined by these SNPs, for the development of systemic lupus erythematosus (SLE) and specific sub-phenotypes (nephritis, antiphospholipid antibody positive, arthritis and double-stranded DNA positive) within a multiethnic US cohort of 1036 patients. Family based analyses were performed using 844 simplex families from four ethnic groups (Caucasian, Asian, Hispanic and African American). Subjects… CONTINUE READING