Association of PAI-1 4G/5G and -844G/A gene polymorphism and changes in PAI-1/tPA levels in stroke: a case-control study.

@article{Saidi2007AssociationOP,
  title={Association of PAI-1 4G/5G and -844G/A gene polymorphism and changes in PAI-1/tPA levels in stroke: a case-control study.},
  author={Sarra Saidi and Lamia B. Slamia and Touhami Mahjoub and Sofyan B. Ammou and Wassim Youssef Almawi},
  journal={Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association},
  year={2007},
  volume={16 4},
  pages={153-9}
}
Mutations in the plasminogen activator inhibitor-1 (PAI-1) gene, along with altered PAI-1 and tissue-type plasminogen activator (tPA) levels, have been implicated in stroke pathogenesis. We investigated the association of PAI-1 and tPA levels with stroke as a function of PAI-1 4G/5G and -844G/A genotypes, as well as the link between these PAI-1 gene variants and stroke risk, in a case-control study of 135 ischemic stroke patient, diagnosed according to clinical and radiologic findings and… CONTINUE READING
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