Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.

@article{Dujic2015AssociationOO,
  title={Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.},
  author={Tanja Dujic and Kaixin Zhou and Louise A. Donnelly and R. D. Tavendale and Colin N A Palmer and Ewan Robert Pearson},
  journal={Diabetes},
  year={2015},
  volume={64 5},
  pages={1786-93}
}
Metformin is the most widely prescribed medication for the treatment of type 2 diabetes (T2D). However, gastrointestinal (GI) side effects develop in ~25% of patients treated with metformin, leading to the discontinuation of therapy in ~5% of cases. We hypothesized that reduced transport of metformin via organic cation transporter 1 (OCT1) could increase metformin concentration in the intestine, leading to increased risk of severe GI side effects and drug discontinuation. We compared the… CONTINUE READING
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of metformin : progress , problems and potential

  • K Zhou, C Bellenguez, CC Spencer
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