Association of OPRM1 A118G variant with the relative reinforcing value of nicotine

@article{Ray2006AssociationOO,
  title={Association of OPRM1 A118G variant with the relative reinforcing value of nicotine},
  author={Riju Ray and C. H. Jepson and Freda Patterson and Andrew A. Strasser and Margaret Rukstalis and Katie Perkins and Kevin Lynch and Stephanie O’Malley and Wade H. Berrettini and Caryn Lerman},
  journal={Psychopharmacology},
  year={2006},
  volume={188},
  pages={355-363}
}
The endogenous opioid system has been implicated in substance abuse and response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the association of the functional OPRM1 A118G variant with the relative reinforcing value of nicotine and (2) the main and interacting effects of the mu-opioid receptor antagonist naltrexone on nicotine reinforcement. In a within-subject, double-blind human laboratory study, 30 smokers of each OPRM1 genotype (A/A vs. A/G or G/G) participated… CONTINUE READING

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