Association of NFE2L2 and KEAP1 haplotypes with amyotrophic lateral sclerosis.

@article{Bergstrm2014AssociationON,
  title={Association of NFE2L2 and KEAP1 haplotypes with amyotrophic lateral sclerosis.},
  author={Petra Bergstr{\"o}m and Malin von Otter and Staffan Nilsson and A Nilsson and Michael W Nilsson and Peter Munch Andersen and Ola Hammarsten and Henrik Zetterberg},
  journal={Amyotrophic lateral sclerosis & frontotemporal degeneration},
  year={2014},
  volume={15 1-2},
  pages={130-7}
}
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron syndrome influenced by oxidative stress. The transcription factor Nrf2 and its repressor Keap1 constitute an important defence system in cellular protection against oxidative stress. Here we hypothesize that common genetic variations in the genes NFE2L2 and KEAP1, encoding Nrf2 and Keap1… CONTINUE READING