Association of NF-κB polymorphisms with clinical outcome of non-medullary thyroid carcinoma.

@article{Plantinga2017AssociationON,
  title={Association of NF-κB polymorphisms with clinical outcome of non-medullary thyroid carcinoma.},
  author={Theo S Plantinga and Mirela S Petrulea and Marije Oosting and Leo A B Joosten and Doina Piciu and Jan Smit and Romana T Netea-Maier and Carmen Emanuela Georgescu},
  journal={Endocrine-related cancer},
  year={2017},
  volume={24 7},
  pages={307-318}
}
The NF-κB inflammatory pathway plays a major role in cancer development and clinical progression. Activation of NF-κB signaling is promoted by NFKB1 and inhibited by NFKBIA. The present study aimed to determine the relevance of NFKB1 rs4648068 and NFKBIA rs2233406 genetic variants for non-medullary thyroid cancer (NMTC) susceptibility, progression and clinical outcome. This case-control and cohort study consists of a Romanian discovery cohort (157 patients and 258 controls) and a Dutch… CONTINUE READING