Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes.

@article{HayaishiOkano2003AssociationON,
  title={Association of NAD(P)H oxidase p22 phox gene variation with advanced carotid atherosclerosis in Japanese type 2 diabetes.},
  author={Rieko Hayaishi-Okano and Yoshimitsu Yamasaki and Yoshitaka Kajimoto and Ken'ya Sakamoto and Kentaro Ohtoshi and Naoto Katakami and Dan Kawamori and Takeshi Miyatsuka and Masahiro Hatazaki and Yoji Hazama and Masatsugu Hori},
  journal={Diabetes care},
  year={2003},
  volume={26 2},
  pages={458-63}
}
OBJECTIVE To evaluate the association between the C242T polymorphism of the p22 phox gene, an essential component of NAD(P)H oxidase in the vasculature, with intima-media thickness (IMT) of the carotid artery and risk factors for atherosclerosis in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS C242T polymorphism of the p22 phox gene was detected by polymerase chain reaction-restriction fragment-length polymorphism in 200 Japanese type 2 diabetic subjects and 215 nondiabetic subjects… CONTINUE READING

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