Association of N-glycosylation with breast carcinoma and systemic features using high-resolution quantitative UPLC.

@article{Saldova2014AssociationON,
  title={Association of N-glycosylation with breast carcinoma and systemic features using high-resolution quantitative UPLC.},
  author={Radka Saldova and Akram Asadi Shehni and Vilde Drageset Haakensen and Israel Steinfeld and Mark Hilliard and Ilona Kifer and {\AA}slaug Helland and Zohar Yakhini and Anne-Lise B\orresen-Dale and Pauline M. Rudd},
  journal={Journal of proteome research},
  year={2014},
  volume={13 5},
  pages={2314-27}
}
An improved separation of the human serum N-glycome using hydrophilic interaction chromatography technology with UPLC is described, where more than 140 N-glycans were assigned. Using this technique, serum samples from 107 healthy controls and 62 newly diagnosed breast cancer patients were profiled. The most statistically significant alterations were observed in cancer patients compared with healthy controls: an increase in sialylation, branching, and outer-arm fucosylation and a decrease in… CONTINUE READING
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Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue.

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