Association of N‐acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug‐induced hepatotoxicity in Western India

@article{Gupta2013AssociationON,
  title={Association of N‐acetyltransferase 2 and cytochrome P450 2E1 gene polymorphisms with antituberculosis drug‐induced hepatotoxicity in Western India},
  author={Vinod H. Gupta and D. Amarapurkar and Meenakshi Singh and P. Sasi and J. Joshi and R. Baijal and Praveenkumar H Ramegowda and A. Amarapurkar and K. Joshi and P. Wangikar},
  journal={Journal of Gastroenterology and Hepatology},
  year={2013},
  volume={28}
}
Tuberculosis (TB) is a major public health problem in India. Despite the treatment availability and monitoring, drug‐induced hepatotoxicity (DIH) is a serious concern and can lead to discontinuation of treatment. Anti‐TB DIH is well known and can aggravate because of pharmacokinetic and pharmacodynamic interactions. Genetic polymorphism in the drug‐metabolizing enzyme genes is an important factor that predisposes certain fraction of the population to drug‐induced toxicity. The purpose of this… Expand
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