Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc.

Abstract

The Myc protein activates transcription as part of a complex with its partner protein, Max. Myc-transformed cells are also characterised by the loss of expression of a number of genes and this repressive effect of Myc on gene expression may not be mediated by the Myc/Max complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that… (More)

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