Association of Monosodium Glutamate Intake With Overweight in Chinese Adults: The INTERMAP Study

@article{He2008AssociationOM,
  title={Association of Monosodium Glutamate Intake With Overweight in Chinese Adults: The INTERMAP Study},
  author={Ka He and Liancheng Zhao and Martha L. Daviglus and Alan Richard Dyer and Linda Van Horn and Daniel B. Garside and Liguang Zhu and Dong-shuang Guo and Yangfeng Wu and Bei-fan Zhou and Jeremiah Stamler},
  journal={Obesity},
  year={2008},
  volume={16}
}
Animal studies indicate that monosodium glutamate (MSG) can induce hypothalamic lesions and leptin resistance, possibly influencing energy balance, leading to overweight. [...] Key Method We conducted a cross-sectional study involving 752 healthy Chinese (48.7% women), aged 40-59 years, randomly sampled from three rural villages in north and south China. The great majority of participants prepared their foods at home, without use of commercially processed foods.Expand
Consumption of monosodium glutamate in relation to incidence of overweight in Chinese adults: China Health and Nutrition Survey (CHNS).
TLDR
MSG consumption was positively, longitudinally associated with overweight development among apparently healthy Chinese adults, and mixed effects models were constructed to estimate change in BMI. Expand
Monosodium glutamate is not associated with overweight in Vietnamese adults
TLDR
It was demonstrated that overweight was not associated with MSG intake in Vietnamese adults, and factors associated with overweight were age, region of residence, lifelong occupation, physical activity and intakes of energy, carbohydrates, saturated fat and animal protein. Expand
Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
TLDR
Higher amounts of individual MSG consumption are associated with the risk of having the metabolic syndrome and being overweight independent of other major determinants. Expand
Monosodium glutamate intake is inversely related to the risk of hyperglycemia.
TLDR
It is suggested that high MSG intake is associated with a decreased risk of hyperglycemia in Chinese adults, even after adjustment for a number of covariates, including dietary patterns. Expand
Monosodium glutamate is not associated with obesity or a greater prevalence of weight gain over 5 years: findings from the Jiangsu Nutrition Study of Chinese adults
TLDR
Findings indicate that when other food items or dietary patterns are accounted for, no association exists between MSG intake and weight gain. Expand
Association between monosodium glutamate intake and sleep-disordered breathing among Chinese adults with normal body weight.
TLDR
The intake of MSG may increase the risk of SDB in Chinese adults with a normal body weight and there was a joint effect between MSG and overweight in relation to SDB. Expand
Monosodium glutamate intake increases hemoglobin level over 5 years among Chinese adults
TLDR
MSG intake may have independent Hb-increasing effects, especially among men and those anemic at baseline, and there was a significant inverse association between MSG intake and the risk of anemia at follow-up. Expand
Is there a relationship between dietary MSG obesity in animals or humans?
TLDR
Overall, it appears that normal dietary MSG use is unlikely to influence energy intake, body weight or fat metabolism. Expand
Monosodium Glutamate Affects Metabolic Syndrome Risk Factors on Obese Adult Rats: A Preliminary Study
TLDR
A relevant effect of MSG intake on abdominal fat and liver weight as well as liver lipid content was demonstrated in this study. Expand
MONOSODIUM GLUTAMATE EFFECT ON WOMEN WEIGHT GAIN AND REPRODUCTIVE ORGAN
TLDR
This review reveal that even though there were evidence that MSG produce negative effect such as weight gain, cell inflammation, damage of reproductive organ in female animal samples, no generalized conclusion published to provide necessities of MSG prohibition in human foods is revealed. Expand
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TLDR
It is hypothesized that it is not the protein, but the amino acid glutamate that determines the propensity of obesity, and the recommended daily allowances of protein and amino acids, particularly during pregnancy are reconsidered. Expand
Enhancing data on nutrient composition of foods eaten by participants in the INTERMAP study in China, Japan, the United Kingdom, and the United States.
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It was possible to expand, enhance, and adjust the nutrient databases from the four countries to produce comparable (60 nutrients) or nearly comparable (ten nutrients) data on composition of all foods reported by INTERMAP participants. Expand
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It is demonstrated for the first time that a widely used nutritional monosubstance – the flavouring agent MSG – at concentrations that only slightly surpass those found in everyday human food, exhibits significant potential for damaging the hypothalamic regulation of appetite, and thereby determines the propensity of world-wide obesity. Expand
Regulation of Adipsin and Body Composition in the Monosodium Glutamate (MSG)-Treated Mouse
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Caffeine clearly depressed intake, caused weight loss, and increased serum adipsin, but similar results were achieved by restricting intake, and none of the adrenergic drugs tested changed serum adipin. Expand
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TLDR
The findings suggest that leptin mediates some physiological actions related to fat mobilization via receptors located in the ANH, which is important in regulating appetite and adiposity. Expand
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TLDR
Dietary quality control procedures yielded data generally indicative of high quality performance in the four countries, and use of tape recorded dietary interviews contributed to quality control, despite feasibility problems, deemed remediable by protocol modification. Expand
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TLDR
In a cross-sectional epidemiologic study of 4680 men and women aged 40–59 years from 17 diverse population samples in China, Japan, UK, and USA, prior hypotheses on relations of macronutrients to SBP/DBP and on role of dietary factors in inverse associations of education with BP are tested. Expand
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The general use of glutamate salts (monosodium-L-glutamate and others) as food additive can be regarded as harmless for the whole population and further research work should be done concerning the effects of high doses of a bolus supply at presence of an impaired blood brain barrier function. Expand
Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: The INTERMAP Study
TLDR
Comparing nutrient intakes among Chinese, Japanese, UK, and US INTERMAP samples, and assessing possible relationships of dietary patterns to differential patterns of cardiovascular diseases between East Asian and Western countries found that both dietary patterns have aspects that can be regarded as adverse and protective in relation to the major adult cardiovascular diseases. Expand
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Evidence is found that the thrifty phenotype may be the consequence of fetal hyperglutamatemia, and abandoning the flavoring agent monosodium glutamate and reconsidering the recommended daily allowances of protein and amino acids during pregnancy is strongly suggested. Expand
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