Association of Monosodium Glutamate Intake With Overweight in Chinese Adults: The INTERMAP Study

  title={Association of Monosodium Glutamate Intake With Overweight in Chinese Adults: The INTERMAP Study},
  author={Ka He and Liancheng Zhao and Martha L. Daviglus and Alan R Dyer and Linda Van Horn and Daniel B. Garside and Liguang Zhu and Dong-shuang Guo and Yangfeng Wu and Bei-fan Zhou and Jeremiah Stamler},
Animal studies indicate that monosodium glutamate (MSG) can induce hypothalamic lesions and leptin resistance, possibly influencing energy balance, leading to overweight. [] Key Method We conducted a cross-sectional study involving 752 healthy Chinese (48.7% women), aged 40-59 years, randomly sampled from three rural villages in north and south China. The great majority of participants prepared their foods at home, without use of commercially processed foods.

Monosodium glutamate is not associated with overweight in Vietnamese adults

It was demonstrated that overweight was not associated with MSG intake in Vietnamese adults, and factors associated with overweight were age, region of residence, lifelong occupation, physical activity and intakes of energy, carbohydrates, saturated fat and animal protein.

Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population

Higher amounts of individual MSG consumption are associated with the risk of having the metabolic syndrome and being overweight independent of other major determinants.

Monosodium glutamate is not associated with obesity or a greater prevalence of weight gain over 5 years: findings from the Jiangsu Nutrition Study of Chinese adults

Findings indicate that when other food items or dietary patterns are accounted for, no association exists between MSG intake and weight gain.

Monosodium Glutamate Affects Metabolic Syndrome Risk Factors on Obese Adult Rats: A Preliminary Study

A relevant effect of MSG intake on abdominal fat and liver weight as well as liver lipid content was demonstrated in this study.


This review reveal that even though there were evidence that MSG produce negative effect such as weight gain, cell inflammation, damage of reproductive organ in female animal samples, no generalized conclusion published to provide necessities of MSG prohibition in human foods is revealed.

Monosodium Glutamate Intake, Dietary Patterns and Asthma in Chinese Adults

A ‘Traditional’ food pattern was positively associated with asthma among Chinese adults, and there was no significant association between MSG intake and asthma.

Monosodium glutamate is related to a higher increase in blood pressure over 5 years: findings from the Jiangsu Nutrition Study of Chinese adults

MSG intake may have independent BP-increasing effects, especially among women and those taking hypertension medications at baseline and follow-up, and in those chronically taking antihypertensive medications.

Epidemiological Studies of Monosodium Glutamate and Health

It is difficult to make a conclusion on the relation between monosodium glutamate and health in free-living subjects since from five surveys, two found no associations while three found associations, and results of these studies have been controversial.



Does High Glutamate Intake Cause Obesity?

It is hypothesized that it is not the protein, but the amino acid glutamate that determines the propensity of obesity, and the recommended daily allowances of protein and amino acids, particularly during pregnancy are reconsidered.

Enhancing data on nutrient composition of foods eaten by participants in the INTERMAP study in China, Japan, the United Kingdom, and the United States.

  • S. SchakelB. Dennis J. Stamler
  • Medicine
    Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems
  • 2003

Obesity, voracity, and short stature: the impact of glutamate on the regulation of appetite

It is demonstrated for the first time that a widely used nutritional monosubstance – the flavouring agent MSG – at concentrations that only slightly surpass those found in everyday human food, exhibits significant potential for damaging the hypothalamic regulation of appetite, and thereby determines the propensity of world-wide obesity.

Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage.

The findings suggest that leptin mediates some physiological actions related to fat mobilization via receptors located in the ANH, which is important in regulating appetite and adiposity.

INTERMAP: the dietary data—process and quality control

Dietary quality control procedures yielded data generally indicative of high quality performance in the four countries, and use of tape recorded dietary interviews contributed to quality control, despite feasibility problems, deemed remediable by protocol modification.

INTERMAP: background, aims, design, methods, and descriptive statistics (nondietary)

In a cross-sectional epidemiologic study of 4680 men and women aged 40–59 years from 17 diverse population samples in China, Japan, UK, and USA, prior hypotheses on relations of macronutrients to SBP/DBP and on role of dietary factors in inverse associations of education with BP are tested.

Nutrient intakes of middle-aged men and women in China, Japan, United Kingdom, and United States in the late 1990s: The INTERMAP Study

Comparing nutrient intakes among Chinese, Japanese, UK, and US INTERMAP samples, and assessing possible relationships of dietary patterns to differential patterns of cardiovascular diseases between East Asian and Western countries found that both dietary patterns have aspects that can be regarded as adverse and protective in relation to the major adult cardiovascular diseases.

Does the thrifty phenotype result from chronic glutamate intoxication? A hypothesis

Evidence is found that the thrifty phenotype may be the consequence of fetal hyperglutamatemia, and abandoning the flavoring agent monosodium glutamate and reconsidering the recommended daily allowances of protein and amino acids during pregnancy is strongly suggested.

The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin.

It is shown that an intact arcuate nucleus is necessary for leptins actions on food intake and body weight and that MSG-treated rats were unresponsive to leptin treatment.