Association of MicroRNAs and YRNAs With Platelet Function.

  title={Association of MicroRNAs and YRNAs With Platelet Function.},
  author={Dorothee Kaudewitz and Philipp Skroblin and Lukas H Bender and Temo Barwari and Peter Willeit and Raimund Pechlaner and Nicholas P Sunderland and Karin Willeit and Allison C. Morton and Paul C J Armstrong and Melissa V Chan and Ruifang Lu and X Cindy Yin and Filipe Gr{\'a}cio and Katarzyna A Dudek and Sarah R. Langley and Anna Zampetaki and Emanuele de Rinaldis and Shu Ye and Timothy D Warner and Alka Saxena and Stefan Kiechl and Robert F. Storey and Manuel Mayr},
  journal={Circulation research},
  volume={118 3},
RATIONALE Platelets shed microRNAs (miRNAs). Plasma miRNAs change on platelet inhibition. It is unclear whether plasma miRNA levels correlate with platelet function. OBJECTIVE To link small RNAs to platelet reactivity. METHODS AND RESULTS Next-generation sequencing of small RNAs in plasma revealed 2 peaks at 22 to 23 and 32 to 33 nucleotides corresponding to miRNAs and YRNAs, respectively. Among YRNAs, predominantly, fragments of RNY4 and RNY5 were detected. Plasma miRNAs and YRNAs were… CONTINUE READING
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