Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Bone Mineral Density in Postmenopausal Japanese Women

@article{Miyao2000AssociationOM,
  title={Association of Methylenetetrahydrofolate Reductase (MTHFR) Polymorphism with Bone Mineral Density in Postmenopausal Japanese Women},
  author={Mariko Miyao and Hiroyuki Morita and Takayuki Hosoi and Hidemi Kurihara and Satoshi Inoue and Shinjiro Hoshino and M Shiraki and Yuka Yazaki and Yasuyoshi Ouchi},
  journal={Calcified Tissue International},
  year={2000},
  volume={66},
  pages={190-194}
}
The pathogenesis of osteoporosis is controlled by genetic and environmental factors. Considering the high prevalence of osteoporosis in homocystinuria, abnormal homocysteine metabolism would contribute to the pathogenesis of osteoporosis. It is known that the polymorphism of methylenetetrahydrofolate reductase (MTHFR), the enzyme catalyzing the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, correlates with hyperhomocysteinemia. In this study, we examined the… CONTINUE READING