Association of Matrix Metalloproteinase-3 -1171(5A>6A) Polymorphism with Cancer Risk: A Meta-Analysis of 41 Studies

@inproceedings{Yang2014AssociationOM,
  title={Association of Matrix Metalloproteinase-3 -1171(5A>6A) Polymorphism with Cancer Risk: A Meta-Analysis of 41 Studies},
  author={Xiaodong Yang and Jing-Wen Hu and Man-Tang Qiu and Ming Li and Rong Yin and Jie Wang and Linlin Xu and Qin Zhang},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND AND OBJECTIVE Evidence has shown that matrix metalloproteinases-3 (MMP3) is important for cancer progression. Recent studies about the association between the -1171(5A>6A) polymorphism in MMP3 promoter region and cancer risk have yielded conflicting results. METHODOLOGY/PRINCIPAL FINDINGS We performed a meta-analysis of 41 studies including 11112 cases and 11091 controls to determine whether the -1171(5A>6A) polymorphism of MMP3 was associated with cancer risk. We assessed the… CONTINUE READING

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