Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population

@article{Sukla2012AssociationOM,
  title={Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population},
  author={Krishna Kishore Sukla and R. Raja Raman},
  journal={European Journal of Clinical Nutrition},
  year={2012},
  volume={66},
  pages={111-118}
}
Background/Objectives:Unlike most Western populations, MTHFR 677T is a rare allele and a risk factor for a variety of disorders in India. What kind of nutritional (environmental) and/or genetic factors could contribute to the genetic risk is not known. To assess the incidence of hyperhomocysteinemia and its correlation with the polymorphism in homocysteine (Hcy)-pathway genes and associated cofactors in the native populations of eastern India.Subjects/Methods:Healthy population from four… CONTINUE READING
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