• Corpus ID: 51825986

Association of MTHFR Gene Variants with Autism

  title={Association of MTHFR Gene Variants with Autism},
  author={Marvin Boris and Allan Goldblatt and Joseph A. Galanko and S. Jill James},
Autism is a complex neurodevelopment disorder with numerous possible genetic and environmental influences. We retrospectively examined the laboratory data of 168 children sequentially referred to our facility with a confirmed diagnosis of autism or pervasive developmental disabilities (PDD). Since folate and methylation (single carbon metabolism) are vital in neurological development, we routinely screened children for the common mutations of the methylenetetrahydrofolate reductase gene (MTHFR… 

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