Association of MTHFR C677T and A1298C polymorphisms with the development of type 2 diabetic nephropathy and their interaction with environmental factors

Abstract

Type 2 diabetic nephropathy is a major cause of end-stage renal disease. MTHFR plays a vital role in folate metabolism, DNA methylation, and RNA synthesis. The aim of this study was to investigate the association between MTHFR C677T and A1298C genomic polymorphisms and development of type 2 diabetic nephropathy in a Chinese population. A hospital-based case… (More)

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