Association of MMP-3 (-1612 5A/6A) polymorphism with knee osteoarthritis in Thai population

@article{Honsawek2012AssociationOM,
  title={Association of MMP-3 (-1612 5A/6A) polymorphism with knee osteoarthritis in Thai population},
  author={Sittisak Honsawek and Somkiat Malila and Pongsak Yuktanandana and Aree Tanavalee and Benjamad Deepaisarnsakul and Javad Parvizi},
  journal={Rheumatology International},
  year={2012},
  volume={33},
  pages={435-439}
}
Osteoarthritis (OA) is a degenerative joint disorder resulting in destruction of articular cartilage, osteophyte formation, and subchondral bone sclerosis. In recent years, numerous genetic factors have been identified and implicated in causing osteoarthritis. One such genetic defect is a single nucleotide polymorphism at position -1612 of matrix metalloproteinase-3 (MMP-3) promoter region, known to lead to three possible genotypes, 5A/5A, 6A/6A, and 5A/6A. The purpose of this study was to… CONTINUE READING