Association of MHC Class I chain-related A (MIC-A) gene polymorphism with Type I diabetes

  title={Association of MHC Class I chain-related A (MIC-A) gene polymorphism with Type I diabetes},
  author={Giovanni Gambelunghe and Mandana Ghaderi and Anna Cosentino and Ad. Falorni and Paolo Brunetti and Al. Falorni and Carani Balaraman Sanjeevi},
Aims/hypothesis. A distinct family of MHC genes has been identified in the class III region and denominated MHC Class I chain-related genes (MIC). The MIC-A gene is located between the TNFA and the HLA-B genes. The aim of our study was to test the association of the polymorphism of the MIC-A gene with Type I (insulin-dependent) diabetes mellitus and evaluate the interaction between MIC-A and TNFA, HLA-B, HLA-DR and HLA-DQ gene polymorphism.¶Methods. Type I diabetic (n = 95) and healthy (n = 98… CONTINUE READING
25 Citations
55 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 25 extracted citations


Publications referenced by this paper.
Showing 1-10 of 55 references

Crystal structure of the MHC class I homolog MICA , a g d T cell ligand

  • N Zwirner, M Fernandez-Vina, P Statsny
  • Immunity
  • 1999

Similar Papers

Loading similar papers…