Association of MDR 1 gene polymorphism ( G 2677 T ) with chronic myeloid leukemia

@inproceedings{Sailaja2012AssociationOM,
  title={Association of MDR 1 gene polymorphism ( G 2677 T ) with chronic myeloid leukemia},
  author={Kagita Sailaja and Damineni Surekha and Dunna Nageswara Rao and Digimarti Raghunadharao and Satti Vishnupriya},
  year={2012}
}
Imatinib mesylate is the most opted drug used for treating ph+ve chronic myeloid leukemia (CML) patients. The up-regulation of drug transporters (ABCB1-ABCG2) is one of specific causes of Imatinib resistance. Imatinib (IM) is a substrate of the P-glycoprotein pump, which is encoded by MDR1/ABCB1 gene. Our main objective is to investigate the influence of MDR1 gene polymorphisms in CML patients. A total of 262 CML and 252 control samples were analysed for MDR1 gene (G2677T) polymorphism using… CONTINUE READING
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