Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer

@inproceedings{Yoneda2013AssociationOM,
  title={Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer},
  author={Tomoko Yoneda and AYUMI KUBOYAMA and Kiyoko Kato and Tatsuhiro Ohgami and Kanako Okamoto and Toshiaki Saito and Norio Wake},
  booktitle={Oncology reports},
  year={2013}
}
The incidence of endometrial cancer, a common gynecological malignancy, is increasing in Japan. We have previously shown that the ER/MDM2/p53/p21 pathway plays an important role in endometrial carcinogenesis. In the present study, we investigated the effects of germline single nucleotide polymorphisms in murine double minute 2 (MDM2) SNP309, TP53 Arg72Pro, ESR1 PvuII and XbaI, and p21 codon 31 on endometrial cancer risk. We evaluated these polymorphisms in DNA samples from 125 endometrial… CONTINUE READING

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MDM 2 SNP 309 does not associate with elevated MDM 2 protein expression or breast cancer risk

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