Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians.

@article{Fang2005AssociationOL,
  title={Association of Leu125Val polymorphism of platelet endothelial cell adhesion molecule-1 (PECAM-1) gene & soluble level of PECAM-1 with coronary artery disease in Asian Indians.},
  author={L F Fang and Heming Wei and Sanual H Chowdhury and Nanling Gong and Jie Song and C. K. Heng and Sunit Sethi and Tian Hai Koh and Subroto Chatterjee},
  journal={The Indian journal of medical research},
  year={2005},
  volume={121 2},
  pages={92-9}
}
BACKGROUND & OBJECTIVES Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes (diapedesis) during vascular inflammation. We hypothesized that genetic variation and the level of soluble PECAM-1 could be associated with the development of atherosclerosis and conducted a study on gene polymorphisms of PECAM-1 and soluble PECAM-1 levels in Asian Indian patients with coronary artery disease (CAD) in Singapore. METHODS… CONTINUE READING

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