Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation.

@article{Park2002AssociationOL,
  title={Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation.},
  author={Brian J. Park and Nhan T. Nguyen and Parmesh Dutt and Keith D. Merdek and Mariam Bashar and Paola Sterpetti and Alessandra Tosolini and Joseph R Testa and Deniz Toksoz},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 47},
  pages={45361-70}
}
The Rho GTPase signaling pathway is required for actin cytoskeletal organization and serum response factor-dependent gene transcription. Lbc is a Rho-specific guanine nucleotide exchange factor that contains a modulatory C-terminal region. To elucidate Lbc regulatory mechanism(s), a yeast two-hybrid screen for proteins that interact with the Lbc C-terminal region was carried out, resulting in multiple isolation of cDNAs encoding the same 734-amino acid Lbc interacting protein. The Lbc… CONTINUE READING

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