Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers.

@article{Goel2006AssociationOJ,
  title={Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers.},
  author={Ajay Goel and Mei-Shu Li and Takeshi Nagasaka and Sung Kwan Shin and Florentine C Fuerst and Luigi Ricciardiello and Linda Wasserman and Clement Richard Boland},
  journal={Gastroenterology},
  year={2006},
  volume={130 7},
  pages={1950-61}
}
BACKGROUND & AIMS JC virus (JCV) is a polyomavirus that ubiquitously infects humans and has been implicated in various human cancers. JCV encodes a "transforming" gene, T-antigen (T-Ag), which is believed to mediate the oncogenic potential of the virus. We have previously shown that JCV DNA sequences are usually present in human colorectal cancers (CRCs), and we have provided in vitro evidence that JCV can induce chromosomal instability (CIN) in CRC cells. This study tests the hypothesis that… CONTINUE READING
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