Association of ITPA gene polymorphisms and the risk of ribavirin-induced anemia in HIV/hepatitis C virus (HCV)-coinfected patients receiving HCV combination therapy.

@article{Domingo2012AssociationOI,
  title={Association of ITPA gene polymorphisms and the risk of ribavirin-induced anemia in HIV/hepatitis C virus (HCV)-coinfected patients receiving HCV combination therapy.},
  author={Pere Domingo and Josep Mar{\'i}a Guardiola and Juliana Salazar and Ferran Torres and Mar{\'i}a Gracia Mateo and Cristina Pacho and Mar{\'i}a del Mar Gutierrez and Karuna Lamarca and Angels Fontanet and Jordi Delgado Mart{\'i}n and J. M. Munoz and F. Javier S{\'a}nchez Vidal and Montserrat Baiget},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 6},
  pages={2987-93}
}
Polymorphisms of the ITPA gene have been associated with anemia during combination therapy in hepatitis C virus (HCV)-monoinfected patients. Our aim was to confirm this association in HIV/HCV-coinfected patients. In this prospective, observational study, 73 HIV/HCV-coinfected patients treated with pegylated interferon plus ribavirin (RBV) were enrolled. Two single nucleotide polymorphisms within or adjacent to the ITPA gene (rs1127354 and rs7270101) were genotyped. The associations between the… CONTINUE READING
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Variants in the ITPA gene protect against ribavirininduced hemolytic anemia in HIV/HCV-coinfected patients with all HCV genotypes

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IL 28 B but not ITPA polymorphism is predictive of response to pegylated interferon , ribavirin , and telaprevir triple therapy in patients with genotype 1 hepatitis C

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