Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy.

@article{Hsu2011AssociationOI,
  title={Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy.},
  author={Ching-Sheng Hsu and Shih-Jer Hsu and Hung-Chia Chen and T. L. Tseng and Chen-Hua Liu and Wenquan Niu and Jenher Jeng and Chun-Jen Liu and M W-Y Lai and Pei-Jer Chen and Jia-Horng Kao and D. -S. Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 9},
  pages={3719-24}
}
Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear. We enrolled 145 consecutive Taiwanese patients with CHC receiving Peg-IFN α-2a plus ribavirin for the study. Blood samples were taken more frequently at defined intervals in the… CONTINUE READING

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