Association of IL12B risk haplotype and lack of interaction with HLA-Cw6 among the psoriasis patients in India

  title={Association of IL12B risk haplotype and lack of interaction with HLA-Cw6 among the psoriasis patients in India},
  author={Aditi Chandra and Swapan Senapati and Saurabh Ghosh and G. Chatterjee and R. Chatterjee},
  journal={Journal of Human Genetics},
Psoriasis is a complex multifactorial chronic inflammatory skin disorder involving both genetic and environmental susceptibility factors. It is strongly associated with HLA-Cw6, but several studies suggested that further genetic factors may confer additional risk. We investigated the association of two single-nucleotide polymorphisms (SNPs), rs3212227 at the 3′-untranslated region and rs7709212 located at ~6.7 kb upstream from the transcription start site of IL12B gene in a case-control study… Expand
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