Association of IL-6 gene polymorphisms and COPD in a Spanish population.


Interleukin-6 (IL-6) is a potential mediator of systemic effects of Chronic Obstructive Pulmonary Disease (COPD). In the present case-control study we investigated the association of promoter polymorphisms of this gene and COPD in a cohort of 191 patients, smokers without COPD (n=75) and a healthy control population (n=296). Besides spirometry, exercise capacity (6MWD, 6 min walking distance) and body mass index (BMI) were measured in COPD patients. Genotyping of the IL-6 polymorphisms at positions -174, -572 and -597 was performed. The -597G/A and -174G/C polymorphisms were not associated with the disease. However, the -572G/C polymorphism was significantly associated with COPD susceptibility under a dominant model of inheritance. The frequency of the genotypes containing the C allele was significantly lower in the COPD cases (9.9%) compared with the healthy control group (16.9%) and smokers (23.1%), (OR=0.46, p=0.032 and OR=0.28, p=0.012, respectively). The GCG (-597/-572/-174) haplotype was significantly associated with the disease (OR=0.37, p=0.022, COPD cases vs. healthy subjects and OR=0.17, p=0.011, COPD cases vs. smokers). Moreover, a borderline association was also found for the -572G allele and hypoxemia (PaO(2)<60 mmHg) (p=0.05). Our data suggest that the IL-6 -572C allele may confer a diminished risk of developing COPD.

DOI: 10.1016/j.rmed.2008.06.012
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@article{CrdobaLans2008AssociationOI, title={Association of IL-6 gene polymorphisms and COPD in a Spanish population.}, author={Elizabeth C{\'o}rdoba-Lan{\'u}s and Juan-Pablo de-Torres and Celeste L{\'o}pez-Aguilar and Mar{\'i}a-Cristo Rodr{\'i}guez-P{\'e}rez and Nicole Maca-Meyer and Angela Montejo-de-Garcini and Armando Aguirre-Ja{\'i}me and Lina Inmaculada P{\'e}rez-M{\'e}ndez and Ciro Casanova}, journal={Respiratory medicine}, year={2008}, volume={102 12}, pages={1805-11} }