Association of IL-10 gene polymorphisms and susceptibility to Juvenile Idiopathic Arthritis in Egyptian children and adolescents: a case-control study

@inproceedings{Fathy2017AssociationOI,
  title={Association of IL-10 gene polymorphisms and susceptibility to Juvenile Idiopathic Arthritis in Egyptian children and adolescents: a case-control study},
  author={Manar M. Fathy and Hosam F. Elsaadany and Yasser Fathy Ali and Mohsen A. A. Farghaly and Mohammed E. Hamed and Hany E. Ibrahim and Maha Abdulaziz Noah and Mayy A. N. Allah and Shaimaa S. A. Elashkar and Nasser I. Abdelsalam and Hind M. Abdelrahman and Ahmed Ragab Ahmed and Heba G. Anany and Sanaa M. Ismail and Boshra R. Ibrahim and Nashwa M A Al Azizi and Heba H. Gawish and Ghada Mohamed Al-Akad and Rehab M. Nabil and Dalia S. Fahmy and Salah F. Alsayed},
  booktitle={Italian journal of pediatrics},
  year={2017}
}
BACKGROUND Juvenile Idiopathic Arthritis (JIA) is the most common chronic arthritis in children worldwide. Among anti-inflammatory cytokines, interleukin-10 (IL-10) is a key immunosuppressive cytokine involved in the pathogenesis of JIA. To date, only a few studies concerned the association of interleukin-10 gene polymorphisms with JIA. In this study, we aimed to investigate 3 cytokine single-nucleotide polymorphisms situated at positions -1082(G/A), -819(C/T), and -592(C/A) in the promoter… CONTINUE READING
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