Association of IL-1β -511 polymorphism with severe veno-occlusive disease in pediatric-matched allogeneic hematopoietic stem cell transplantation.

@article{Elbahlawan2012AssociationOI,
  title={Association of IL-1β -511 polymorphism with severe veno-occlusive disease in pediatric-matched allogeneic hematopoietic stem cell transplantation.},
  author={Lama M Elbahlawan and Jennifer A. McArthur and Michael W. Quasney and Deqing Pei and Kumar Srivastava and Mary K Dahmer and Raymond Carlton Barfield},
  journal={Journal of pediatric hematology/oncology},
  year={2012},
  volume={34 3},
  pages={175-9}
}
Single nucleotide polymorphisms (SNPs) of the interleukin 1 (IL-1) family have been implicated in acute graft-versus-host disease and mortality postallogeneic hematopoietic stem cell transplantation (HSCT) in adults. Hepatic veno-occlusive disease (VOD) is a well-known complication of HSCT and can result in an increased risk of mortality. In this study, we sought to investigate the association of both patient and donor genotypes at the IL-1β -511 cytidine/thymidine (C/T) polymorphic site with… CONTINUE READING
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