Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk

@article{Feik2009AssociationOI,
  title={Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk},
  author={Elisabeth Feik and Andreas Baierl and Barbara Hieger and Gerhard F{\"u}hrlinger and Astrid Pentz and Stefan Staettner and Werner W. Weiss and Thomas Pulgram and Gernot Leeb and Karl Mach and Michael Micksche and Andrea Gsur},
  journal={Cancer Causes & Control},
  year={2009},
  volume={21},
  pages={91-97}
}
Insulin-like growth factor 1 (IGF1) is a peptide growth factor that promotes cell proliferation and inhibits apoptosis. The bioavailability of IGF1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer. In this ongoing colorectal cancer study of Austria (CORSA), a total of… CONTINUE READING

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